Sitting Interruption and Whole-body Cardiovascular Health

Summary

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Conditions

• Sedentary Behavior
• Sedentary Time

Interventions

BEHAVIORAL

One 5-Minute Walking Bout Each Hour

One 5-minute light intensity walking break per hour throughout the 4-hour SB condition

BEHAVIORAL

One 15-Minute Standing Bout Each Hour

One 15-minute standing break per hour throughout the 4-hour SB condition

BEHAVIORAL

One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour

Two breaks per hour throughout the 4-hour SB condition, alternating between a 5-minute light intensity walking break and a 15-minute standing break

BEHAVIORAL

Uninterrupted Sitting

No breaks will be provided throughout the 4-hour SB condition. This will be used as the control condition

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• University of North Carolina, Chapel Hill

  lead OTHER

Principal Investigators

• Erik Hanson, PhD · University of North Carolina, Chapel Hill

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

30 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-08-15

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• United States

Study Locations