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Oxidative Stress Expression and Metabolic Imbalance in Critically Ill Polytrauma Patients and the Implications of Antioxidant Therapy on Clinical Outcomes

NCT03218280 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2019-03-07

No results posted yet for this study

Summary

Critically ill polytrauma patients have a number of physiological disorders secondary to trauma, such as systemic inflammatory response (SIRS), adult respiratory distress syndrome (ARDS), sepsis, oxidative stress (OS), and finally the multiple organ dysfunction syndrome (MODS). Another important aspect in terms of clinical outcome is the energy-metabolic status. Numerous studies have shown that implementing antioxidant therapy, capable of reducing the expression of pro-oxidative, pro-inflammatory and energetic-metabolic status, the mortality rate in critical patients decreases statistically significant. In this research paper, will be implemented a multimodal monitoring protocol that covers the use of biochemical, genetics and epigenetics biomarkers and the use of non-invasive medical devices to assess and monitor critical polytrauma patient. Also will be optimized the antioxidant treatment plan according to the needs of each patient.

Conditions

  • Oxidative Stress
  • Polytrauma

Interventions

DRUG

Vitamin C

Sponsors & Collaborators

  • University of Medicine and Pharmacy "Victor Babes" Timisoara

    collaborator OTHER

  • Romanian Society of Anesthesia and Intensive Care

    lead OTHER

Principal Investigators

  • Alexandru Rogobete, MSc, PhDs, Clinical Researcher · Emergency County Hospital Pius Brinzeu, Clinic of Anesthesia and Intensive Care

  • Ovidiu Bedreag, MD, PhD, Assist Prof · Victor Babes University of Medicine and Pharmacy Timisoara

  • Dorel Sandesc, MD, PhD, Prof · Romanian Society of Anesthesia and Intensive Care

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2019-11-30
Completion
2019-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03218280 on ClinicalTrials.gov