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Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance

NCT07341789 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-01-14

No results posted yet for this study

Summary

The aim of this study was to determine the effects of a new formulation of vitamin B12, natural orange extract, and their combination on physical and mental performance.

Conditions

  • Vitamin b12
  • Supplementation During Endurance Performance
  • Flavonoids
  • Mental Fatigue
  • Biomarker Feedback

Interventions

DIETARY_SUPPLEMENT

Vitamin B 12

Subjects in this group will intake 1 mg/day of vitamin B12.

DIETARY_SUPPLEMENT

Natural orange extract

Subjects in this groups will intake 500 mg/day of natural orange extract.

COMBINATION_PRODUCT

Vitamina B12 + natural orange extract

This group will take the combination of vitamin B12 and Vitamina B12 (1 mg/day) + natural orange extract (500 mg/day).

DIETARY_SUPPLEMENT

Microcrystalline Cellulose

Microcrystalline cellulose was used, this molecule was selected to avoid affecting the glycemia, as it can occur with dextrose or maltodextrin.

Sponsors & Collaborators

  • Francisco Javier Martínez Noguera

    lead OTHER

Principal Investigators

  • Francisco Javier Martinez Noguera, PhD · Universidad Católica San Antonio de Murcia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-04-30
Completion
2026-06-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07341789 on ClinicalTrials.gov