Prevalence Survey of Antimalarial Drug Resistance Markers

Summary

Study is cross-sectional and observational with one-time dried-blood spot sample collection from persons with laboratory-confirmed uncomplicated Plasmodium falciparum malaria (mixed or monoinfection). Samples will be analysed for the presence of molecular markers of resistance to ACT partner drugs (gene amplifications and/or other mutations in pfmdr1, gene amplifications of pfpm2, and additional mutations which may be identified during the course of the trial) in the first instance. Testing to detect additional markers of antimalarial drug resistance will also be performed where feasible. Prevalence of mutations will be summarized and mapped to provide intelligence on antimalarial drug resistance in the region of interest.

Conditions

• Malaria

Interventions

DIAGNOSTIC_TEST

Blood Collection

blood smear and/or rapid diagnostic

DIAGNOSTIC_TEST

Dried Blood Spot

Dried Blood Spot on filter paper

Sponsors & Collaborators

• Mahidol University

  collaborator OTHER

• Worldwide Antimalarial Resistance Network

  collaborator NETWORK

• Mahidol Oxford Tropical Medicine Research Unit

  collaborator OTHER

• Myanmar Oxford Clinical Research Unit

  collaborator OTHER

• Shoklo Malaria Research Unit

  collaborator OTHER

• Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

  collaborator OTHER

• Oxford University Clinical Research Unit, Vietnam

  collaborator OTHER

• Cambodia Oxford Medical Research Unit

  collaborator UNKNOWN

• University of Oxford

  lead OTHER

Principal Investigators

• Francois Nosten, Prof · Shoklo Malaria Research Unit

• Frank Smithuis, Prof · Myanmar Oxford Clinical Research Unit

• Mayfong Mayxay, Prof · Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

• Nguyen Thanh Thuy Nhien, Dr · Oxford University Clinical Research Unit, Vietnam

• Arjen M. Dondorp, PhD · Mahidol Oxford Clinical Research Unit

Eligibility

Min Age

6 Months

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-09-18

Primary Completion

2021-12-24

Completion

2021-12-24

Countries

• Thailand

Study Locations