Targeted Chemo-elimination (TCE) of Malaria

Summary

The overall aim of this study is two fold:

1. to pilot targeted chemo-elimination of plasmodium falciparum malaria in known areas of artemisinin resistance in South East Asia.
2. to understand the micro-epidemiology of malaria in these areas; chiefly, the prevalence and importance to on-going transmission of sub-clinical p.f malaria infections.

Conditions

• Plasmodium Falciparum Malaria

Interventions

DRUG

malaria elimination using DP and low-dose primaquine

Treatment of all persons resident in the intervention villages including those who do not have malaria parasites as detected by rapid diagnostic test. This is to interrupt p.f malaria transmission by removing the reservoir of all potentially infectious people from the area.

Sponsors & Collaborators

• Mahidol Oxford Tropical Medicine Research Unit

  collaborator OTHER

• National Centre for Parasitology, Entomology and Malaria Control, Cambodia

  collaborator OTHER

• FHI 360

  collaborator OTHER

• Oxford University Clinical Research Unit, Vietnam

  collaborator OTHER

• National Malaria Control Program, Vietnam

  collaborator OTHER_GOV

• Myanmar Oxford Clinical Research Unit

  collaborator OTHER

• National Malaria Control Program, Myanmar

  collaborator OTHER_GOV

• Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

  collaborator OTHER

• Shoklo Malaria Research Unit

  collaborator OTHER

• University of Oxford

  lead OTHER

Principal Investigators

• Nicholas J White, PhD · University of Oxford

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

6 Months

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-04-30

Primary Completion

2017-07-31

Completion

2017-07-31

Countries

• Burma
• Cambodia
• Laos
• Thailand
• Vietnam

Study Locations