Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis

Summary

The purpose of this study is to investigate the effect of low-intensity BFR exercise on joint pain, muscle mass, and mechanical muscle function compared to standard rehabilitering in adults with knee-OA.

Conditions

• Osteoarthritis, Knee

Interventions

OTHER

BFR (Blood-Flow Restricted exercise)

The BFR group performs unilateral training with the knee-OA diagnosed leg first. BFR exercise is performed with a pneumatic cuff placed at the top of the thigh on the leg being trained. The cuff will be inflated to 60-80 % of the total arterial occlusion pressure (AOP). The participant will afterwards perform training of the knee extensors in a leg press exercise machine and a leg extension exercise machine with a load corresponding to 30 % of the maximal load (1RM = Repetition Maximum).

OTHER

Standard rehabilitation

The GLA:D programme involves a circuit training program with four stations. Each station involves two to six exercises where the participants perform 10-15 repetitions over 2-3 sets, which depends on the participants pain- and functional level. Following the 8 weeks GLA:D programme, participants will continue 4 weeks of team group training performing similar neuromuscular lower limb exercises as for the first 8 weeks.

Sponsors & Collaborators

• University of Southern Denmark

  collaborator OTHER

• Gigtforeningen

  collaborator OTHER

• Sygekassernes Helsefond

  collaborator OTHER

• AP Moeller Foundation

  collaborator OTHER

• Aase and Ejnar Danielsens Foundation

  collaborator OTHER

• Praksisfonen

  collaborator UNKNOWN

• FAPS

  collaborator UNKNOWN

• Bispebjerg Hospital

  lead OTHER

Principal Investigators

• Finn E Johannsen, MD · Institute of Sports Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-01-01

Primary Completion

2025-01-15

Completion

2025-02-14

Countries

• Denmark

Study Locations