Effects of Exercise and Education in Patients With Chronic Pain After Total Knee Replacement

Summary

The purpose of the study is to investigate whether a 12-week neuromuscular rehabilitation program (NEMEX-TJR) combined with pain neuroscience education (PNE) provides greater pain relief, improvement in physical function and quality of life than PNE alone in a population of patients with chronic pain after primary total knee arthroplasty.

Hypothesis: Rehabilitation involving neuromuscular training and PNE will provide greater pain relief, improved function and improved quality of life compared to PNE alone at the primary endpoint, which is follow-up 12months after the start of the treatment.

Conditions

• Arthroplasty, Replacement, Knee
• Chronic Pain

Interventions

OTHER

Neuromuscular exercises (NEMEX-TJR) and pain neuroscience education

60min. of neuromuscular exercises (NEMEX-TJR) training two times a week for 3 months (12 weeks, 24 sessions). Physiotherapists will instruct and supervise the participants during the neuromuscular exercises. The aim of the neuromuscular exercise program is to restore normal movement, improve sensorimotor control, re-establishing normal motor program strategies and muscle activation. 60min. of pain neuroscience education at the beginning of intervention period and after 6 weeks. Both sessions will take 60min. and will be conducted by physiotherapists. The aim of the pain neuroscience education is to increase the pain neuroscience knowledge of the patients leading to a better understanding of their chronic pain and thereby engaging the patients in the treatment of their chronic pain and impaired function.

OTHER

Pain neuroscience education

60min. of pain neuroscience education at the beginning of intervention period and after 6 weeks. Both sessions will take 60min. and will be conducted by physiotherapists. The aim of the pain neuroscience education is to increase the pain neuroscience knowledge of the patients leading to a better understanding of their chronic pain and thereby engaging the patients in the treatment of their chronic pain and impaired function.

Sponsors & Collaborators

• Northern Orthopaedic Division, Denmark

  collaborator OTHER

• The Danish Rheumatism Association

  collaborator OTHER

• Svend Andersen Foundation

  collaborator UNKNOWN

• Lions Denmark

  collaborator UNKNOWN

• Aalborg University

  lead OTHER

Principal Investigators

• Pascal Madeleine, Dr.Scient · Aalborg University

• Søren T Skou, PhD · University of Southern Denmark and Næstved-Slagelse-Ringsted Hospitals

• Ole Simonsen, Dr.Med · Aalborg University Hospital

• Lars Arendt-Nielsen, Dr.Med · Aalborg University

• Jesper B Larsen, M.Sc. · Aalborg University

• Mogens B Laursen, PhD · Aalborg University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-04-01

Primary Completion

2023-02-21

Completion

2024-04-08

Countries

• Denmark

Study Locations