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Stress CMR Perfusion Imaging in the United States (SPINS) Study

NCT03192891 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2349

Last updated 2025-12-30

Study results available
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Summary

Numerous single-center studies have indicated gadolinium-enhanced stress CMR perfusion imaging has excellent diagnostic accuracy for coronary artery disease and negative clinical event rates, with its diagnostic accuracy exceeding nuclear scintigraphy. However, current prognostic evidence supporting clinical use of stress CMR is limited by study size, single-center settings with a predominance of academic centers, and a lack of "real-world" study design. Large-scale multicenter real-world evidence from a registry will provide the much needed information to guide evidence-based clinical adaptation that benefits patient care.

Conditions

  • Myocardial Ischemia

Interventions

DIAGNOSTIC_TEST

Stress cardiac magnetic resonance (CMR) perfusion imaging

Gadolinium-enhanced stress CMR perfusion imaging is a tool increasingly used for the risk assessment and diagnosis of coronary artery disease.

Sponsors & Collaborators

  • Siemens Medical Solutions

    collaborator INDUSTRY

  • Bayer

    collaborator INDUSTRY

  • Society for Cardiovascular Magnetic Resonance

    lead OTHER

Principal Investigators

  • Raymond Y Kwong, MD, MPH · Brigham and Women's Hospital

Eligibility

Min Age
35 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-01
Primary Completion
2019-11-30
Completion
2019-11-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03192891 on ClinicalTrials.gov