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Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction

NCT00808535 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2009-02-09

No results posted yet for this study

Summary

The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion deficits and/or abnormalities in myocardial blood flow (MBF) in patients with endothelial dysfunction.

This is a controlled study, which will enroll approximately 60 subjects (30 diabetics and 30 non-diabetics to serve as healthy controls), and will include male and non-pregnant females, between the ages 18-50 years.

All eligible participants will sign an informed consent and will complete a Lifestyle Questionnaire. They will undergo blood work which includes:

* 2-hour Oral Glucose Tolerance Test and Fasting Labs for Glucose, Insulin, C-Peptide, HbA1c, Creatinine, and Lipid Panel.
* Urine Albumin to Creatinine ratio for microalbuminuria.
* Serum inflammatory markers: E-selectin, homocysteine, ADMA, VCAM, IL-6, TNFalpha, hs-CRP and PAI-1.

After blood work, all participants will undergo cardiac MR perfusion imaging procedure with Cold Pressor Test and Adenosine Stress Test.

Conditions

  • Endothelial Dysfunction
  • Myocardial Perfusion Abnormalities
  • Cardiac MRI Perfusion With Vasomotor Stress
  • Diabetes

Interventions

PROCEDURE

Cardiac Perfusion MRI w Vasomotor Stress

All participants will undergo Cardiac Perfusion MRI with Vasomotor Stress. Vasomotor Stress will include both Cold Pressor Test and Adenosine Stress Test.

Sponsors & Collaborators

Principal Investigators

  • Stefan Ruehm, MD · University of California, Los Angeles

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2010-02-28
Completion
2010-03-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00808535 on ClinicalTrials.gov