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Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

NCT03176732 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 155

Last updated 2023-04-26

No results posted yet for this study

Summary

Hypertension is a common consequence of obstructive sleep apnea (OSA). However, not all individuals with OSA have hypertension and there are major individual differences in blood pressure response to positive airway pressure treatment of OSA. This project is focused on determining the basis of these individual differences in blood pressure response to OSA and will evaluate the possible underlying reasons for these differences. The results will help clinicians to know whether or not to expect a reduction in blood pressure (BP) to OSA treatment in a given patient and thereby personalize patient management.

Conditions

Interventions

DEVICE

Positive Airway Pressure

Participants will use Positive Airway Pressure (PAP) treatment

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Pennsylvania

    lead OTHER

Principal Investigators

  • Samuel T Kuna, MD · University of Pennsylvania

  • Raymond R Townsend, MD · University of Pennsylvania

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-06
Primary Completion
2022-04-30
Completion
2022-06-30

Countries

  • United States
  • Iceland

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03176732 on ClinicalTrials.gov