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Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

NCT05067088 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 267

Last updated 2025-08-06

No results posted yet for this study

Summary

Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA). Our preliminary data suggest that physiological causes of OSA such as easy arousability (low arousal threshold) or unstable breathing control (high loop gain) may influence effectiveness of OSA's most common treatment, continuous positive airway pressure (CPAP). The NICE-PAP study will examine how the physiologic traits that cause OSA in each individual impact CPAP effectiveness and can lead to personalized OSA treatments that improve patient lives.

Conditions

Interventions

OTHER

CPAP (all patients receive CPAP as part of routine clinical care)

Continuous positive airway pressure

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Andrey Zinchuk, MD, MHS · Yale University

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-01
Primary Completion
2026-01-30
Completion
2026-08-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05067088 on ClinicalTrials.gov