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Non-specific Effects of Vaccination on Mortality and Morbidity

NCT03176719 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1005

Last updated 2018-09-04

No results posted yet for this study

Summary

It has long been recognized that the positive effects of vaccination on childhood mortality cannot be solely attributed to a decline in the disease targeted by the vaccine. These so-called non-specific effects of vaccination have so far mostly been linked to mortality. However, it has been suggested that non-specific effects may also effect morbidity and nutritional status. This study aims to further explore the correlation between vaccination, susceptibility to infectious diseases (particularly malaria and bacterial infections), nutritional status and immunity.

With this prospective cross sectional study among healthy individuals in rural west-Africa we aim to address several research questions at the same time. This study will assess the influence of (time-point of) vaccination on morbidity, mortality and immune status among healthy individuals in a rural sub-Saharan African setting. Secondly, to explore the prevalence of subclinical malaria, iron deficiency anemia, sickle cell anemia and thallasemia among a healthy rural sub-Saharan African population. And finally to assess normal hemocytometry values among a healthy rural sub-Saharan African population.

Conditions

  • Vaccine Reaction
  • Anemia
  • Malaria,Falciparum
  • Salmonella Bacteraemia

Interventions

OTHER

Venipuncture

1. Full blood count and leukocyte differentiation. 2. Detection of malaria parasites and parasite differentiation to trophozoites, gametocytes and ringstages (XN-30) 3. Detection of anemia, thallasemia and sickle cell anemia (XN-20) 4. Ex-vivo stimulation of wholeblood with various stimuli. Read-out will be a spectrum of cytokines (ELISA) 5. Circulating cytokines and inflammatory markers (ELIZA) 6. DNA analysis to assess genetic variations determining pro- versus anti inflammatory response including mTOR, HK2, PFKP, GLS, and GLUD1/2. 7. pan-Salmonella PCR 8. Gametocyte PCR

Sponsors & Collaborators

  • Clinical Research Unit of Nanoro

    collaborator UNKNOWN

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • André van der Ven, Prof. Dr. · Radboud University Medical Center

Eligibility

Min Age
1 Year
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-17
Primary Completion
2017-10-31
Completion
2018-12-31

Countries

  • Burkina Faso

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03176719 on ClinicalTrials.gov