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Macrophage Polarization in Response to Macronutrient Intake in Healthy Humans: A Randomized Clinical Study

NCT03173677 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2017-06-02

No results posted yet for this study

Summary

Macrophages can exhibit distinct phenotypes and functions in response to stimuli and can polarize into one of three distinct phenotypes: a pro-inflammatory (M1), an anti-inflammatory pro-tissue (M2) and metabolically-activated (MMe) macrophage phenotypes. Thirty-six healthy volunteers were recruited and randomized into one of three macronutrient intake groups (glucose, lipids, proteins). This study measured the effects of macronutrient intake on the macrophage differentiation.

Conditions

Interventions

DIETARY_SUPPLEMENT

Lipid Intake

90 grams whipping cream, 31.5 grams fat, 1.7 grams protein, and 2.25 grams carbohydrate

DIETARY_SUPPLEMENT

Glucose intake

300 calories of glucose

DIETARY_SUPPLEMENT

Protein intake

Isopure unflavored Whey proteins isolate (WPI) powder containing 26 grams per serving of 100% WPI, stripped of fat, carbs, fillers, sugars, and lactose

Sponsors & Collaborators

  • King Saud Bin Abdulaziz University for Health Sciences

    lead OTHER

Principal Investigators

  • Awad Alshahrani, MD · Ministry of Natioanl Guard Health Affairs

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-02
Primary Completion
2016-04-24
Completion
2016-04-29

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03173677 on ClinicalTrials.gov