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Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

NCT03160274 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2025-10-15

No results posted yet for this study

Summary

Pheochromocytomas and paragangliomas are neural crest-derived tumors of the nervous system that are often inherited and genetically heterogeneous. Genetic screening is recommended for patients and their relatives, and can guide clinical decisions. However, a mutation is not found in all cases. The aims of this proposal are to: 1) to map gene(s) involved in pheochromocytoma, and 2) identify genotype-phenotype correlations in patients with pheochromocytoma/paraganglioma of various genetic origins.

Conditions

  • Pheochromocytoma
  • Paraganglioma
  • Inherited Cancer Syndrome
  • Associated Conditions
  • Kidney Neoplasms
  • Bone Cancer
  • Thyroid Neoplasms
  • Other Cancer

Interventions

GENETIC

Genetic screening

Germline and/or tumor samples will be screened for mutations

Sponsors & Collaborators

  • National Institute of General Medical Sciences (NIGMS)

    collaborator NIH

  • The Paradifference Foundation

    collaborator UNKNOWN

  • National Cancer Institute (NCI)

    collaborator NIH

  • The University of Texas Health Science Center at San Antonio

    lead OTHER

Principal Investigators

  • Patricia L Dahia, MD, PhD · The University of Texas Health Science Center at San Antonio

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-10-19
Primary Completion
2030-12-31
Completion
2030-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03160274 on ClinicalTrials.gov