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Rare Genetic Disorders of the Breathing Airways

NCT00323167 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 367

Last updated 2022-08-10

No results posted yet for this study

Summary

Mucociliary clearance, in which mucus secretions are cleared from the breathing airways, is the primary defense mechanism for the lungs. Inhaled particles, including microbes that can cause infections, are normally entrapped in mucus on the airway surfaces and then cleared out by the coordinated action of tiny hair-like structures called cilia. Individuals with primary ciliary dyskinesia, variant cystic fibrosis, and pseudohypoaldosteronism have defective mucociliary clearance. The purpose of this study is to collect clinical and genetic information about these three airway diseases to improve current diagnostic procedures.

Conditions

  • Kartagener Syndrome
  • Cystic Fibrosis
  • Pseudohypoaldosteronism
  • Primary Ciliary Dyskinesia

Sponsors & Collaborators

  • Rare Diseases Clinical Research Network

    collaborator NETWORK

  • National Center for Research Resources (NCRR)

    collaborator NIH

  • National Institutes of Health (NIH)

    collaborator NIH

  • University of North Carolina, Chapel Hill

    lead OTHER

Principal Investigators

  • Michael R Knowles, MD · University of North Carolina, Chapel Hill

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-05-31
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • United States
  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00323167 on ClinicalTrials.gov