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Pharmacogenetic Algorithm for Individualized Controlled Ovarian Stimulation

NCT03149536 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1350

Last updated 2020-07-16

No results posted yet for this study

Summary

In this study, the investigators will evaluate genetic variation or polymorphisms between individuals submitted to IVF/ICSI cycles, and how these variations influence response to COS and pregnancy outcomes. Thus, this project has the aim to develop a pharmacogenetic algorithm associating gene polymorphisms, the patient clinical information, and functional and hormonal biomarker to: 1) predict the patient response to gonadotropin; 2) develop individualized gonadotropin regimens; 3) improve the accuracy of determining appropriate dosages of gonadotrophins; 4) improve efficacy and patient compliance to COS; and finally 5) reduce the time-to-pregnancy.

Conditions

Interventions

DIAGNOSTIC_TEST

Pharmacogenetic test

To develop a pharmacogenetic prediction test

Sponsors & Collaborators

  • Faculdade de Medicina do ABC

    collaborator OTHER

  • ANDROFERT - Clinica de Andrologia e Reproducao Humana

    collaborator OTHER

  • Clínica Origen

    lead OTHER

Principal Investigators

  • Matheus Roque, MD · ORIGEN - Center for Reproductive Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
38 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-30
Primary Completion
2021-11-30
Completion
2022-11-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03149536 on ClinicalTrials.gov