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fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study

NCT03126279 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2017-04-24

No results posted yet for this study

Summary

Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement surgery (TKR). The assessment of the brain's response to noxious stimuli using non-invasive functional MRI (fMRI) may be key in identifying imaging biomarkers within the brain that map central sensitization changes seen in OA. fMRI may help explain why up to 20% of patients undergoing TKR surgery develop persistent post-operative pain. To test these concepts the study aims to functionally characterise the brain activity related to temporal summation of pain in healthy individuals and OA patients using a novel fMRI cuff algometer. Assessment of outcomes in terms of pain and function will be performed 6 months post TKR surgery

Conditions

Interventions

PROCEDURE

Total Knee Replacement Surgery

All chronic knee osteoarthritis patients will be recruited as they are on the NHS waiting list for a total knee replacement. Only this group will undergo the procedure

Sponsors & Collaborators

  • Aalborg University

    collaborator OTHER

  • Medical Research Council

    collaborator OTHER_GOV

  • Arthritis Research UK

    collaborator OTHER

  • Royal College of Surgeons of Edinburgh

    collaborator OTHER

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Dorothee P Auer, PhD · The University of Nottingham

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2017-06-30
Completion
2017-08-31

Countries

  • United Kingdom

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03126279 on ClinicalTrials.gov