MedTrace Logo

Sensitization in Osteoarthritic Knees

NCT00379184 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2014-03-31

No results posted yet for this study

Summary

Musculoskeletal pains represent a major part of pain complaints in patients. Moreover, the treatment of musculoskeletal pain conditions by currently available drugs is not optimal (Curatolo and Bogduk 2001). Thus, deep pain is a diagnostic and therapeutic problem, and further insights into the peripheral and central neurophysiologic mechanisms are necessary to improve diagnosis and therapy and to implement a mechanism-based approach. Peripheral sensitization and central hyper excitability are, most likely the important factors for chronic musculoskeletal pain and in particular osteoarthritis (OA).

The focus of this project is to study the involvement of peripheral and central sensitization underlying deep tissue hyperalgesia and referred pain in male and female OA patients.

Adequate quantitative sensory testing assessment techniques for measuring hyper excitability are needed to investigate, in more detail the mechanisms involved in generating the sensitization in OA patients.

Conditions

Sponsors & Collaborators

  • Aalborg University

    collaborator OTHER

  • Northern Orthopaedic Division, Denmark

    lead OTHER

Principal Investigators

  • Mogens B Laursen, MD, PhD · Northern Orthopaedic Division

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2009-04-30
Completion
2009-06-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00379184 on ClinicalTrials.gov