WHISH-2-Prevent Heart Failure

Summary

The WHISH-2-Prevent Heart Failure (HF) study is an ancillary study to the Women's Health Initiative Strong and Healthy (WHISH) exercise pragmatic trial. The WHISH-2-Prevent HF trial examines the intervention effect of physical activity (PA) on both incident HF and HF burden (recurrent HF and CVD death in those with HF) in a cost effective manner in elderly women. In addition, it will allow a dose-finding analysis to better understand the type, intensity and frequency of PA that leads to a reduced risk and burden of HF. The focus of the parent WHISH trial is on atherosclerotic cardiovascular disease and not heart failure.

Conditions

• Physical Activity
• Heart Failure
• Heart Failure With Reduced Ejection Fraction
• Heart Failure With Normal Ejection Fraction
• Strength Training
• Elderly
• Women

Interventions

BEHAVIORAL

Physical Activity

Physical activity intervention based upon stage of change and social cognitive theory based interventions

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Stanford University

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• Fred Hutchinson Cancer Center

  collaborator OTHER

• University of North Carolina, Chapel Hill

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• University of California, San Diego

  collaborator OTHER

• University at Buffalo

  collaborator OTHER

• Wake Forest University

  collaborator OTHER

• Memorial Hospital of Rhode Island

  lead OTHER

Principal Investigators

• Charles B Eaton, MD, MS · Memorial Hospital of Rhode Island

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

66 Years

Max Age

102 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-04-15

Primary Completion

2020-09-01

Completion

2021-07-01

Countries

• United States

Study Locations