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Reducing Heart Failure Risk in Late-Life With Physical Activity

NCT06247774 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2026-03-12

No results posted yet for this study

Summary

The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.

The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.

The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:

* Cardiopulmonary exercise test (CPET)
* Echocardiogram
* Physical function test
* 6-minute walk test
* Hand grip strength
* Quality of life questionnaire
* Blood draws

Researchers will compare results between those who do and don't participate in the exercise program.

Conditions

  • Hypertension
  • Exercise Training
  • Cardiac Rehabilitation
  • Proteomics

Interventions

BEHAVIORAL

Cardiac Rehabilitation

Participation in a 12-week cardiac rehabilitation program

BEHAVIORAL

Attention Control

Participants will receive regular phone calls in place of cardiac rehabilitation visits

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Sheila Hegde, MD · Brigham and Women's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2029-01-31
Completion
2029-05-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06247774 on ClinicalTrials.gov