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Modulation of Steroid Immunosuppression by Alveolar Efferocytosis

NCT03034642 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2022-05-03

No results posted yet for this study

Summary

The long-term goals of this study are (a) to understand the biological underpinnings for the increased incidence of community-acquired pneumonia in patients with chronic obstructive pulmonary disease (COPD) who are treated with inhaled corticosteroids; and (b) to develop novel therapies to treated this problem using over-expression of micro-RNAs (miRNAs).

Conditions

  • Pulmonary Disease, Chronic Obstructive
  • Pneumonia, Bacterial

Interventions

PROCEDURE

Bronchoscopy with bilateral bronchoalveolar lavages

Bronchoscopy with bilateral bronchoalveolar lavages

Sponsors & Collaborators

Principal Investigators

  • Jeffrey L. Curtis, M.D. · University of Michigan

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-10-01
Primary Completion
2020-03-20
Completion
2021-12-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03034642 on ClinicalTrials.gov