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Pharmacokinetics of Ciprofloxacin in Critically Ill Patients

NCT03016845 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2020-10-19

No results posted yet for this study

Summary

Optimal understanding of ciprofloxacin pharmacokinetics in critically ill patients is lacking resulting in large variation of achieved exposure and possible inadequate therapy. The investigators hypothesize that drug dosing based on CKD-EPIcr-cys provides a useful method to individualize and optimize therapy for ciprofloxacin and eventually improve outcome.

In a multi-centre, observational, open-label study the investigators aim to define : the model for estimation of renal function that most accurately predicts ciprofloxacin clearance in critically ill patients.

Conditions

Sponsors & Collaborators

  • Canisius-Wilhelmina Hospital

    collaborator OTHER

  • UMC Utrecht

    collaborator OTHER

  • Gelderse Vallei Hospital

    collaborator OTHER

  • Tergooi Hospital

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • Roger Bruggemann · Radboud University Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2018-03-01
Completion
2018-04-01

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03016845 on ClinicalTrials.gov