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2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)

NCT01582360 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 640

Last updated 2015-10-16

No results posted yet for this study

Summary

The main purpose of the study is to examine if changes in pharmacokinetics of important antiinfectives in Critically Ill patients in need of continuous renal replacement therapy (CRRT), causes inadequate concentrations in plasma.

The effect of different modus of CRRT: CVVH and CVVHD will be compared, as well as type of filter, filter lifetime etc.

Hypothesis: The risk of incorrect dosage of antiinfectives - to low/ to high- is increased in critically ill patients receiving CRRT. Inadequate plasma concentrations of antiinfectives may contribute to increased mortality in this group.

Conditions

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Elin Helset, MD PhD · Oslo University Hospital

  • Jan Fr Bugge, MD PhD · Oslo University Hospital

  • Elizabeth von der Lippe, MD PhD · Oslo University Hospital

  • Hilde Ma Sporsem, cand pharm · Sykehusapotekene Oslo

  • Yvonne Lao, cand pharm · Sykehusapotekene Oslo

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2017-01-31
Completion
2018-01-31

Countries

  • Norway

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01582360 on ClinicalTrials.gov