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Sodium Deposition in Soft Tissues of Patients with Kidney Disease

NCT03004547 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2025-02-12

No results posted yet for this study

Summary

Sodium (Na+) hemostasis is abnormal in CKD patients, and this element can be deposited in the skin, muscle, and skeleton - to cope with long term sodium loading. It is known that sodium stored in this non-osmotically active way, is profoundly inflammatory. Furthermore, inflammation has been associated with several uremic symptoms. The investigators will use novel Na+ MRI imaging to examine the Na+ deposition in the skin, muscle, and skeleton of five groups:1) chronic in-center hemodialysis patients, 2) chronic peritoneal dialysis patients, 3) adult and paediatric patients with CKD stage 1-5 and 4) heart failure patients with and without renal dysfunction 5) sex and age-matched healthy adult and paediatric controls. Additionally, they will investigate the association between sodium deposition in these tissues with uremic symptomatology and biochemical markers of metabolism.

Conditions

  • Haemodialysis Complication

Interventions

OTHER

Measuring sodium content

Sodium MRI measurement of sodium content in the tissues of all participants

Sponsors & Collaborators

  • Chris McIntyre

    lead OTHER

Principal Investigators

  • Christopher W McIntyre, PhD, MD · Western University, Canada

Eligibility

Min Age
6 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-05
Primary Completion
2025-12-31
Completion
2026-02-28

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03004547 on ClinicalTrials.gov