Dyspnea Assessment in Hemodialysis Patients

Summary

Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath. The amount of salt in the body tissues, which tends to accumulate in dialysis patients and can also cause shortness of breath, will also be measured. Machines that exploit magnetic resonance, ultrasound and x-rays to take images of the body interior will be employed; in addition, breathing tests, questionnaires and blood tests will also be used. 20 patients on dialysis will be recruited and have two visits: one at the beginning of the study and one year later to observe any changes in the lungs, heart and salt accumulation over time.

Conditions

• Dyspnea; Uremic
• End Stage Renal Disease
• Chronic Lung Disease
• Chronic Heart Disease
• Hemodialysis-Induced Symptom
• Sodium Excess

Interventions

DIAGNOSTIC_TEST

Lung MRI

Proton Lung Magnetic Resonance Imaging

DIAGNOSTIC_TEST

Sodium MRI

Sodium Soft Tissue Magnetic Resonance Imaging

DIAGNOSTIC_TEST

Chest CT

High-resolution Quantitative Chest CT

DIAGNOSTIC_TEST

Echocardiography

Transthoracic 2D Speckle-Tracking Echocardiography

DIAGNOSTIC_TEST

Fractional Exhaled Nitric Oxide

Fractional Exhaled Nitric Oxide testing

DIAGNOSTIC_TEST

Pulmonary Function Tests

Spirometry and Plethysmography

DIAGNOSTIC_TEST

Blood Sampling

Blood testing for: standard-of-care, inflammatory biomarkers, uremic toxins

DIAGNOSTIC_TEST

Six-Minute Walk Test

Six-Minute Walk Test

DIAGNOSTIC_TEST

Dyspnea Questionnaires

Modified Medical Research Council; University of California, San Diego Shortness of Breath Questionnaire; Borg Scale

Sponsors & Collaborators

• London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

  lead OTHER

Principal Investigators

• Christopher W McIntyre, MD PhD · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-03-29

Primary Completion

2020-02-25

Completion

2020-02-25

Countries

• Canada

Study Locations