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Remote Ischemic Preconditioning After Cardiac Surgery

NCT02997748 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2018-01-30

No results posted yet for this study

Summary

Acute kidney injury (AKI) is a well-recognized complication after cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study is to reduce the incidence of AKI by implementing remote ischemic preconditioning and to evaluate the dose-response relationship using the biomarkers urinary \[TIMP-2\] \*\[IGFBP7\] in high risk patients undergoing cardiac surgery.

Conditions

  • Cardiac Surgery, Aortocoronary Bypass

Interventions

PROCEDURE

Remote ischemic preconditioning (RIPC)

3 cycles or more cycles of 5 to 10-min inflation of a blood-pressure cuff to 200 mm HG (or at least to a pressure 50 mmHG higher than the systolic arterial pressure) to one upper arm followed by 5 min reperfusion with the cuff deflated. In Non-Responder two additional cycles of 10 min cuff inflation will be performed in arm 6.

Sponsors & Collaborators

  • Else Kröner Fresenius Foundation

    collaborator OTHER

  • University Hospital Muenster

    lead OTHER

Principal Investigators

  • Melanie Meersch · University Hospital Muenster

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2019-06-30
Completion
2019-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02997748 on ClinicalTrials.gov