Glycaemic Response to Oral Nutrition Support During Haemodialysis

Summary

Patients with kidney, or renal, failure require life-saving treatment with regular dialysis. Dialysis is a form of treatment that simulates some kidney functions; to remove harmful waste products and extra water from the blood. Almost one-third of people with kidney failure also have diabetes, as diabetes is one of the leading causes of kidney disease in the United Kingdom, usually due to poor blood sugar control over a long period of time. Malnutrition is common in patients needing dialysis due to kidney failure causing fatigue, taste changes and a build up of waste products, which can reduce appetite. Treatment of malnutrition involves increasing both the energy and protein intake from food and drinks, and milk-drink style specialist nutrition drinks are often given to dialysis patients due to their specific dietary needs. These nutrition drinks can increase blood sugar levels and optimal control for diabetes may be difficult. This research study aims to measure the blood sugar response to a "slow-release" sugar nutrition drink specifically designed for dialysis patients, which may result in a lower blood sugar level, compared to standard nutrition drinks, consumed during a dialysis session. 28 patients with diabetes and having regular dialysis treatment will enrol in the study. Patients will be asked to drink 1 of 3 different nutrition drinks, once a week for 3 weeks during their regular dialysis treatment. Blood sugar levels will be measured from the blood samples taken from the patient's circulation directly before it enters the dialysis machine over 3 hours and the maximum blood sugar reading and total blood sugar response will be measured. Differences between the 3 drinks will be tested statistically. The results will help to advise patients with diabetes and kidney failure on the most suitable type of nutrition drink to consume during dialysis.

Conditions

• Diabetes
• Chronic Kidney Disease
• End Stage Renal Failure on Dialysis

Interventions

DIETARY_SUPPLEMENT

Nepro HP (Abbott Nutrition)

oral nutritional supplement drink with modified carbohydrate composition

DIETARY_SUPPLEMENT

Fortisip compact protein 125 ml + Calogen 20ml (Nutricia)

Fortisip compact protein 125 ml + Calogen 20ml (Nutricia) oral nutritional supplement drink macronutrient matched with standard carbohydrate composition

DIETARY_SUPPLEMENT

Fortisip compact 125 ml (Nutricia)

Fortisip compact 125 ml (Nutricia) oral nutritional supplement drink - standard

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• King's College Hospital NHS Trust

  lead OTHER

Principal Investigators

• Helen L MacLaughlin, PhD · Clinical Lecturer

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2016-12-31

Completion

2016-12-31

Countries

• United Kingdom

Study Locations