Initial Ventilation Strategy for Adult Immunocompromised Patients With Acute Respiratory Failure

Summary

VENIM is a multicenter, open-label, parallel-group randomized controlled trial of studying the initial ventilation strategy for adult immunocompromised patients with acute respiratory failure.

Conditions

• Immunocompromised Patients
• Acute Respiratory Failure

Interventions

PROCEDURE

Noninvasive mechanical ventilation

Noninvasive mechanical ventilation will be delivered to the patient through a mask. The mask will be adjusted and connected to a ventilation system.

PROCEDURE

Invasive mechanical ventilation

Invasive mechanical ventilation will be initially performed by using the volume controlled mode, and could be adjusted to pressure controlled mode or other modes based on clinical situation.

Sponsors & Collaborators

• National Natural Science Foundation of China

  collaborator OTHER_GOV

• Ministry of Health, China

  collaborator OTHER_GOV

• Fujian Provincial Hospital

  collaborator OTHER

• First Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• The Affiliated Hospital Of Guizhou Medical University

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Tianjin Medical University General Hospital

  collaborator OTHER

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• The Second Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Cangzhou Central Hospital

  collaborator OTHER

• Handan First Hospital

  collaborator OTHER

• Peking Union Medical College Hospital

  lead OTHER

Principal Investigators

• Yi Li, M.D. · PUMC hospital,Chinese Academy of Medical Sciences

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-12-31

Primary Completion

2018-09-30

Completion

2018-12-31