Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)

Summary

Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.

Conditions

• Acute Respiratory Distress Syndrome
• Conventional Mechanical Ventilation
• High Frequency Oscillation Ventilation

Interventions

DEVICE

HFOV

Ventilated infants were randomized to HFOV

DEVICE

CMV

Ventilated infants were randomized to CMV.

Sponsors & Collaborators

• Children's Hospital of Chongqing Medical University

  collaborator OTHER

• Jiulongpo No.1 People's Hospital

  collaborator OTHER

• Chongqing Maternal and Child Health Hospital

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Children's Hospital of The Capital Institute of Pediatrics

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• First Hospital of Tsinghua University

  collaborator OTHER

• Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital

  collaborator OTHER

• First Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• Quanzhou Children's Hospital

  collaborator OTHER

• Xiamen Maternity & Child Care Hospital

  collaborator OTHER

• Zhujiang Hospital

  collaborator OTHER

• Guangdong Academy of Medical Science and General Hospital

  collaborator OTHER

• Guangdong Women and Children Hospital

  collaborator OTHER

• Women and Children's Health Hospital of Yulin

  collaborator OTHER

• Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region

  collaborator OTHER

• Second Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• Guiyang Maternal and Child Health Care Hospital

  collaborator OTHER

• The First People's Hospital of Zunyi

  collaborator OTHER

• Lanzhou University Second Hospital

  collaborator OTHER

• Gansu Provincial Maternal and Child Health Care Hospital

  collaborator OTHER

• LanZhou University

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• Zhengzhou Children's Hospital, China

  collaborator OTHER

• Third Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• the Maternal and Child Health Hospital of Hainan Province

  collaborator OTHER

• Bethune International Peace Hospital

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• Children's Hospital of Nanjing Medical University

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• Children's Hospital of Fudan University

  collaborator OTHER

• Maternal and Children's Healthcare Hospital of Taian

  collaborator OTHER

• The Second Hospital of Shandong University

  collaborator OTHER

• Shanxi Provincial Maternity and Children's Hospital

  collaborator OTHER

• Chengdu Women and Children's Center Hospital

  collaborator OTHER

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• Affiliated Hospital of Southwest Medical University

  collaborator OTHER

• Shenzhen People's Hospital, The Second Medical College of Jinan University

  collaborator OTHER

• Tianjin Central Hospital of Gynecology Obstetrics

  collaborator OTHER

• People's Hospital of Xinjiang Uygur Autonomous Region

  collaborator OTHER

• Kunming Children's Hospital

  collaborator OTHER

• The First People's Hospital of Yunnan

  collaborator OTHER

• First Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• Yan'an Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• Women and Children's Health Hospital of Qujing

  collaborator OTHER

• The People's Hospital of Dehong Autonomous Prefecture

  collaborator OTHER

• The First People's Hospital of Yinchuan

  collaborator OTHER

• The Children's Hospital of Zhejiang University School of Medicine

  collaborator OTHER

• Women's Hospital School Of Medicine Zhejiang University

  collaborator OTHER

• Beijing 302 Hospital

  collaborator OTHER

• Hunan Children's Hospital

  collaborator OTHER_GOV

• Women and Children Hospital of Qinghai Province

  collaborator OTHER

• Jiangxi Province Children's Hospital

  collaborator OTHER

• Inner Mongolia People's Hospital

  collaborator OTHER

• Mianyang Central Hospital

  collaborator OTHER

• People's Liberation Army No.202 Hospital

  collaborator OTHER

• Ningbo Women & Children's Hospital

  collaborator OTHER

• Shanghai Children's Medical Center

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Nanjing Medical University

  collaborator OTHER

• Qinhuangdao Maternal and Child Health Care Hospital

  collaborator OTHER

• Xuzhou Children Hospital

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Xianyang Children's Hospital

  collaborator OTHER

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

1 Minute

Max Age

12 Hours

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-12-31

Primary Completion

2024-12-31

Completion

2024-12-31

Countries

• China

Study Locations