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Study on Mechanisms of Changes in Liver Disease and Sex Steroid Metabolism During Weight Loss

NCT02964780 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2021-12-03

No results posted yet for this study

Summary

The main objective of the study is to gain insight in the early dynamics and mechanisms of recovery of liver disease and sex steroid metabolism during weight loss in obese men and women and to investigate whether surgical weight loss has differential effects as compared to weight loss with life style measures. In addition, we want to evaluate the postprandial hypoglycemic reactive syndrome (PPHRS) in these patients using a standard chewable meal.

Secondary objectives are investigating determinants for the changes in sex steroids, liver disease and PPHRS. Possible determinants to be investigated are adipocytokine secretion patterns, body composition, resting metabolism rate, weight loss per se and changes in fat distribution, parameters of fatty acid metabolism, … .

Conditions

Interventions

PROCEDURE

Gastric bypass surgery

BEHAVIORAL

Conservative weight loss program

Sponsors & Collaborators

  • University Ghent

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-19
Primary Completion
2020-05-05
Completion
2020-05-05

Countries

  • Belgium

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02964780 on ClinicalTrials.gov