Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Summary

This clinical trial tests next generation sequencing (NGS) for the detection of precursor features of pre-myeloid cancers and bone marrow failure syndromes. NGS is a procedure that looks at relevant cancer associated genes and what they do. Finding genetic markers for pre-malignant conditions may help identify patients who are at risk of pre-myeloid cancers and bone marrow failure syndromes and lead to earlier intervention.

Conditions

• Myeloid Malignancy
• Inherited Bone Marrow Failure Syndrome
• Clonal Expansion
• Cytopenia
• Bone Marrow Failure Syndrome
• Clonal Cytopenia of Undetermined Significance
• Clonal Hematopoiesis of Indeterminate Potential
• Hematologic Neoplasms
• Hematopoietic and Lymphatic System Neoplasm
• Hereditary Neoplastic Syndrome
• Idiopathic Cytopenia of Undetermined Significance
• Idiopathic Dysplasia of Uncertain Significance
• Low Risk Myelodysplastic Syndrome

Interventions

PROCEDURE

Biospecimen Collection

Undergo blood sample, hair follicle, and saliva collection

PROCEDURE

Bone Marrow Biopsy

Undergo a bone marrow biopsy

PROCEDURE

Punch Biopsy

Undergo a skin punch biopsy

PROCEDURE

Buccal Swab

Undergo a saliva or buccal swab

OTHER

Clinical Evaluation

Undergo clinical assessment

OTHER

Genetic Counseling

Receive genetic counseling

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Electronic Health Record Review

Ancillary studies

Sponsors & Collaborators

• Mayo Clinic

  lead OTHER

Principal Investigators

• Mrinal S. Patnaik, MBBS · Mayo Clinic

Study Design

Allocation

NA

Purpose

SCREENING

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-16

Primary Completion

2030-09-15

Completion

2035-09-15

Countries

• United States

Study Locations