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Integrating Quantitative Energetics Determines the Microbiome's Contribution to Energy Balance

NCT02939703 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2021-06-30

No results posted yet for this study

Summary

We propose to study the role of the gut microbiome in the development of obesity, and whether we can change the microbiome's contribution to host energy balance through diet. We have created a novel model that explicitly links the effects of microorganisms on human energy balance and modeled weight change, and will use the power of metabolic ward studies to measure small changes in energy absorption, total daily energy expenditure, and/or food intake that affect long-term weight gain or loss. By integrating clinical measurements, bioreactor experiments, and mathematical modeling, we will be able to describe cause-and-effect mechanisms that will enable a quantification of the microbiota's contribution to weight gain and inspire future studies on the interactions of diet, the gut microbiome, and human physiology.

Conditions

Interventions

OTHER

Diet

Participants will consume either a Control Western Diet or a Microbiome Enhancer Diet.

Sponsors & Collaborators

  • Arizona State University

    collaborator OTHER

  • AdventHealth Translational Research Institute

    lead OTHER

Principal Investigators

  • Steven R Smith, MD · Study Principal Investigator

  • Rosa Krajmalnik-Brown, PhD · Study Principal Investigator at Arizona State University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-14
Primary Completion
2019-07-20
Completion
2019-07-23

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02939703 on ClinicalTrials.gov