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CO2 Gap Changes in Septic Shock in Relation to Cardiac Output

NCT05578534 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 76

Last updated 2022-10-13

No results posted yet for this study

Summary

Background The arteriovenous difference of partial pressure of carbon dioxide (PCO2) between mixed or central venous blood and arterial blood is the ∆PCO2 or CO2 gap. Previous data demonstrated a strong relationship between ∆PCO2 and cardiac index (CI) at the very early phase of resuscitation in septic shock. Monitoring the ∆PCO2 from the beginning of the resuscitation may be a useful tool to assess the adequacy of cardiac output (CO) in tissue perfusion.

Aim of work: To examine behavior of ∆PCO2 during early management of septic shock.

Methodology: Seventy-six patients with diagnosis of septic shock admitted to critical care department, Cairo university hospitals. We classified the study population according to initial resuscitation response, initial CO2 gap, or 28-days mortality. The response vs non-response to initial resuscitation, ICU morbidity and recovery rate were the study primary outcomes while secondary outcomes included ICU length of stay (LOS) and 28-day ICU Mortality.

Conditions

  • Septic Shock

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Farouk Faris, MD · Cairo University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2022-09-30
Completion
2022-10-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05578534 on ClinicalTrials.gov