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Sodium Nitrite to Treat Arterial Aging

NCT02022670 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2015-07-15

Study results available
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Summary

The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults. The study also will provide insight into how sodium nitrite therapy improves artery health by determining the physiological mechanisms (biological reasons) involved. Overall, the proposed research will provide important new scientific evidence on the effectiveness of sodium nitrite for decreasing the risk of developing cardiovascular diseases with aging.

Conditions

  • Vascular Aging

Interventions

DRUG

Placebo

Sugar pill manufactured to mimic sodium nitrite capsules

DRUG

Sodium Nitrite

80 mg/d or 160 mg/d

Sponsors & Collaborators

  • TheraVasc Inc.

    collaborator INDUSTRY

  • University of Colorado, Boulder

    lead OTHER

Principal Investigators

  • Douglas R Seals, Ph.D. · University of Colorado, Boulder

  • Allison E DeVan, Ph.D. · University of Colorado, Boulder

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-10-31
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02022670 on ClinicalTrials.gov