Weaning From Noninvasive Ventilation

Summary

Noninvasive ventilation (NIV) weaning strategies differ considerably from one another. These strategies have yet not been compared to each other. Therefore, the investigators planned to perform a prospective, randomized, pilot study involving hypercapnic acute respiratory failure patients ready to be weaned off from NIV. The investigators are going to compare the success rate of NIV weaning and the duration of NIV after randomization between 3 NIV weaning methods: gradual decrease in duration of NIV or level of ventilator support, and abrupt discontinuation of NIV.

Conditions

• Hypercapnic Respiratory Failure
• Weaning Failure
• Noninvasive Ventilation

Interventions

OTHER

Protocol for weaning of noninvasive ventilation

3 protocols for weaning of noninvasive ventilation will be compared

Sponsors & Collaborators

• University of Bologna

  collaborator OTHER

• Marmara University

  collaborator OTHER

• Istanbul Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital

  collaborator OTHER

• Dokuz Eylul University

  collaborator OTHER

• Cukurova University

  collaborator OTHER

• Ospedale San Donato

  collaborator OTHER

• University of Milan

  collaborator OTHER

• Baskent University

  lead OTHER

Principal Investigators

• Stefano Nava · Bologna University

• Begum Ergan · Dokuz Eylul University

• Sait Karakurt · Marmara University

• Ezgi Ozyılmaz · Cukurova University

• Raffaele Scala · San Donato Hospital

• Fabiano Di Marco · Milan University

• Zuhal Karakurt · Sureyyapasa Center for Chest Diseases and Thoracic Surgery Training and Investiagation Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-09-30

Primary Completion

2020-03-31

Completion

2020-03-31

Countries

• Italy
• Turkey (Türkiye)

Study Locations