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Noninvasive Ventilation After Extubation in Hypercapnic Patients

NCT01047852 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 144

Last updated 2015-03-05

No results posted yet for this study

Summary

The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure during spontaneous breathing.

Conditions

Interventions

PROCEDURE

Noninvasive ventilation

NIV will be delivered using a sequential mode (a minimum of 1 hour every 3 hours) immediately after extubation for a schedule period of 48 h after extubation. In between NIV courses ((NIV-free periods) O2 will be administered through nasal cannula in order to obtain a SaO2 ≥ 90%. Afterward, NIV will be withdraw and oxygen will be administered by nasal cannula

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Frédéric VARGAS, MD · University Hospital, Bordeaux, France

  • Olivier GUISSET, MD · University Hospital, Bordeaux, France

  • Marc CLAVEL, MD · University Hospital, Limoges, France

  • Pascale SANCHEZ, MD · University Hospital, Toulouse, France

  • Sylvain GARNIER, MD · Hospital, Libourne, France

  • Aissa KHERCHACHE, MD · Hospital, Agen, France

  • Antoine BENARD, MD · University Hospital, Bordeaux, France

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-05-31
Completion
2011-08-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01047852 on ClinicalTrials.gov