Old Red Blood Cell In Renal Transplantation

Summary

Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population. Deaths recipients are due mainly to cardiovascular diseases related to a chronic inflammatory state. In addition, renal transplant patients frequently have anemia, identified as an independent cardiovascular risk factor that can be corrected by blood transfusion.

But the relationship between transfusion and inflammatory condition are bidirectional. The patient's inflammatory condition will sound on the effectiveness of transfusion and transfusion could trigger an inflammatory condition. This has been reported with the said blood components "aged", especially with packed red cells in patients hospitalized in intensive care after heavy heart surgery.The main objective of this study is to evaluate the impact of early transfusions on the evolution of renal transplantation (ie death, anti-HLA immunization, acute rejection, graft loss, delayed graft function, cardiovascular events ) taking into account in the analysis: patient age at the time of transplantation, the number of incompatibility (s) (HLA class I and / or II) between the graft and the patient and sex of the recipient.

This is a multicenter retrospective observational study (descriptive epidemiological study).The impact of early transfusions is determined retrospectively over a period of 6 years from 01 January 2002 to 31 December 2008, in renal transplant patients of all centers of France met the criteria for inclusion. This cohort represents about 12 000-14 000 patients

Conditions

• Disorder Related to Renal Transplantation
• Transfusion Reaction

Sponsors & Collaborators

• Agence de La Biomédecine

  collaborator OTHER_GOV

• Etablissement Français du Sang

  collaborator OTHER

• Amiens University Hospital

  collaborator OTHER

• University Hospital, Angers

  collaborator OTHER_GOV

• Bicetre Hospital

  collaborator OTHER

• University Hospital, Bordeaux

  collaborator OTHER

• University Hospital, Brest

  collaborator OTHER

• University Hospital, Caen

  collaborator OTHER

• University Hospital, Clermont-Ferrand

  collaborator OTHER

• CRC CHI Creteil France

  collaborator OTHER_GOV

• Centre Hospitalier Universitaire Dijon

  collaborator OTHER

• Hopital Foch

  collaborator OTHER

• University Hospital, Grenoble

  collaborator OTHER

• Groupe Hospitalier Pitie-Salpetriere

  collaborator OTHER

• University Hospital, Lille

  collaborator OTHER

• University Hospital, Limoges

  collaborator OTHER

• Hôpital Edouard Herriot

  collaborator OTHER

• Centre Hospitalier Lyon Sud

  collaborator OTHER

• University Hospital, Marseille

  collaborator OTHER

• University Hospital, Montpellier

  collaborator OTHER

• Central Hospital, Nancy, France

  collaborator OTHER

• Nantes University Hospital

  collaborator OTHER

• Hôpital Necker-Enfants Malades

  collaborator OTHER

• Centre Hospitalier Universitaire de Nice

  collaborator OTHER

• Poitiers University Hospital

  collaborator OTHER

• CHU de Reims

  collaborator OTHER

• Rennes University Hospital

  collaborator OTHER

• CHU de Rouen - Accueil

  collaborator OTHER

• Centre Hospitalier Universitaire de Saint Etienne

  collaborator OTHER

• Saint-Louis Hospital, Paris, France

  collaborator OTHER

• University Hospital, Strasbourg, France

  collaborator OTHER

• Tenon Hospital, Paris

  collaborator OTHER

• University Hospital, Toulouse

  collaborator OTHER

• University Hospital, Tours

  collaborator OTHER

• Centre Hospitalier Universitaire de Besancon

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-01-31

Primary Completion

2008-12-31

Completion

2008-12-31