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Contribution of Renal Function to Endothelial Dysfunction in Living Kidney Donors and Transplant Recipients

NCT02515643 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2017-03-28

No results posted yet for this study

Summary

Endothelial dysfunction one-year after transplantation mainly depends on transplant-associated factors and only marginally on reduced renal function.

OBJETIVES Primary objective Estimate the contribution of renal dysfunction to endothelial dysfunction in two cohorts of patients, living kidney donors and their transplant recipients.

Secondary objectives

To evaluate in both cohorts of patients before and after nephrectomy/transplantation the evolution of the following parameters:

1. Renal function (iohexolGFR, proteinuria/microalbuminuria).
2. Blood pressure (24 h ambulatory blood pressure measurement)
3. Surrogate variables of subclinical atherosclerosis (carotid ultrasound, ankle-brachial index, pulse wave velocity).

DESIGN Non-interventional, prospective, multicenter, longitudinal study of two cohorts: living kidney donors and their transplant recipients.

Conditions

Interventions

OTHER

Endothelial dysfunction

One month before surgery and one year after, the following procedures will be performed in donors and recipients: 1. Blood samples will be obtained for the measurement of endothelial dysfunction and low grade inflammation markers. 2. Atherosclerotic burden: carotid ultrasound to determine the number of plaques and intima-media thickness, carotid-femoral pulse wave velocity (m/s) will be performed by pulse tonometry. 3. Ambulatory blood pressure monitoring with overnight-automated ABPM monitor 4. Estimation of glomerular filtration rate by Iohexol method

Sponsors & Collaborators

  • Teva Pharmaceutical Industries, Ltd.

    collaborator INDUSTRY

  • Hospital Universitari Vall d'Hebron Research Institute

    lead OTHER

Principal Investigators

  • Francesc Moreso, MD, PhD · Hospital Vall d'Hebron

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Spain

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02515643 on ClinicalTrials.gov