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Yeast Cells as Antioxidant-Producing Probiotics

NCT02814695 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-12-29

No results posted yet for this study

Summary

The purpose of this study is to evaluate the efficacy of Baker's yeast extractions , probiotic antioxidant, in scavenging the oxidative stress status mediated damage on sperm motility,progressive motility and vitality as well as comparing this potency to that of Vitamin E in infertile men.

Conditions

  • Infertility, Male

Interventions

DIETARY_SUPPLEMENT

Vit E

0.1ml liquefied semen was mixed with 0.1ml Ham's F10 medium supplemented with (2 mg/ml) Vitamin E and incubated at 37o C for 30 minutes.

DIETARY_SUPPLEMENT

Yeast

0.1ml liquefied semen was mixed with 0.1ml Ham's F10 medium supplemented with (20 mg/ml) yeast extraction and incubated at 37o C for 30 minutes.

DIETARY_SUPPLEMENT

Vit C 1

0.1ml liquefied semen was mixed with 0.1ml Ham's F10 medium supplemented with (0.02 mg/ml) Vitamin C and incubated at 37o C for 30 minutes.

DIETARY_SUPPLEMENT

Vit C 2

0.1ml liquefied semen was mixed with 0.1ml Ham's F10 medium supplemented with (0.04 mg/ml) Vitamin C and incubated at 37o C for 30 minutes.

DIETARY_SUPPLEMENT

Vit C 3

0.1ml liquefied semen was mixed with 0.1ml Ham's F10 medium supplemented with (0.06 mg/ml) Vitamin C and incubated at 37o C for 30 minutes.

Sponsors & Collaborators

  • Hawaa Fertility Center

    collaborator OTHER

  • Zagazig University

    collaborator OTHER_GOV

  • Benha University

    lead OTHER

Principal Investigators

  • Ahmed S Saad, MD · Benha University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
22 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-15
Primary Completion
2021-11-02
Completion
2021-11-09

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02814695 on ClinicalTrials.gov