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The Effect of Lycopene on Sperm Quality in Men Attending Fertility Clinic

NCT05671562 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2026-02-04

No results posted yet for this study

Summary

The goal of this clinical trial is to test whether lycopene (an antioxidant found in cooked tomatoes) will improve the number of swimming sperm in the ejaculates of men with low total motile sperm count.

Participants will take either lycopene capsules or identical capsules containing no lycopene for 12 weeks. We will analyse the quality of their semen before and after taking the capsules, and compare the results.

Hypothesis: Supplementation with lycopene will improve testicular function (semen quality) in males with low total motile sperm count (TMSC).

Conditions

  • Total Motile Sperm Count

Interventions

DIETARY_SUPPLEMENT

Lycopene

Capsule containing lycopene 7mg x 2 daily for 12 weeks

DIETARY_SUPPLEMENT

Placebo

Capsule containing inactive substance 7mg x 2 daily for 12 weeks

Sponsors & Collaborators

  • Health Education England, Wessex

    collaborator OTHER

  • Manchester Metropolitan University

    collaborator OTHER

  • University of Sheffield

    collaborator OTHER

  • Sheffield Teaching Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Lucy Wood · National Health Service, United Kingdom

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-03
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05671562 on ClinicalTrials.gov