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Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway

NCT01684059 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2012-09-12

No results posted yet for this study

Summary

The ability of spermatozoa to produce reactive oxygen species (ROS) has been respected since the 1940's. Oxidative stress limits the functional competence of mammalian spermatozoa via lipid peroxidation, the induction of oxidative DNA damage and the formation of protein adducts. Nitric oxide (NO) is a free radical generated from the oxidation of L-arginine to L-citrulline by reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent NO synthases. Several studies suggest that the overproduction of this free radical and the subsequent excessive exposure to oxidative conditions have a potential pathogenetic implication, which due to the reduction of sperm motility. The present study was conducted to study the effect of Zn supplementation on the levels of NO synthase and arginase in semen of patients with asthenozoospmia.

Conditions

  • Asthenozoospermia

Interventions

DIETARY_SUPPLEMENT

zinc sulfate

every participant took two capsules of zinc sulfate per day for three months (each one 220mg)

Sponsors & Collaborators

  • Ministry of Health, Iraq

    collaborator NETWORK

  • Babylon University

    lead OTHER

Principal Investigators

  • mahmoud H. hadwan, phD · babylon university / Iraq

  • Lamia A. Almashhedy, phD · Babylon university/Iraq

  • abdulrrazaq S. Alsalman, phD · Babylon university/Iraq

Eligibility

Min Age
27 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2012-07-31
Completion
2012-07-31

Countries

  • Iraq

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01684059 on ClinicalTrials.gov