Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly

Summary

The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.

Conditions

• Ageing

Interventions

OTHER

Cardiovascular Magnetic Resonance Imaging (MRI)

Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.

OTHER

Echocardiography

To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.

OTHER

Tonometry

Tonometry is a noninvasive method to obtain arterial pressure waveform

OTHER

Genetic Testing (Blood)

The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.

OTHER

Hand-Grip Strength Measurement

We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.

OTHER

Body Fat Mass Analysis

Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.

Sponsors & Collaborators

• National University of Singapore

  collaborator OTHER

• National Heart Centre Singapore

  lead OTHER

Principal Investigators

• Su-Mei Angela Koh, MBBS · National Heart Centre Singapore

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-07-31

Primary Completion

2017-04-30

Completion

2017-04-30

Countries

• Singapore

Study Locations