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Age-Related Changes in Body Composition

NCT01517113 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2018-04-05

No results posted yet for this study

Summary

Background:

\- Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age. Studies suggest that age-related inflammation may affect fatty tissue in the body. If this fat develops in the muscles or around the heart, it may increase risks of heart disease. Researchers will study body composition in older adults to see if age-related changes in body fat are related to higher risks of heart disease.

Objectives:

\- To study the relationship between fat deposits and aging, and greater risks of heart disease.

Eligibility:

* Participants in the Baltimore Longitudinal Study of Aging between 50 and 80 years of age.
* Individuals between 50 and 80 years of age who have been diagnosed with coronary artery disease.

Design:

* Participants will be screened with a physical exam and medical history.
* Participants will provide blood and urine samples. They will also have their height and weight measured. Waist circumference will also be taken.
* Participants will have a DEXA scan to study their muscles.
* Participants will have magnetic resonance imaging scans. These scans will study heart function and muscle and blood vessel health.
* Participants with coronary artery disease will have catheterization. Blood samples will be collected during the procedure....

Conditions

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    lead NIH

Principal Investigators

  • Luigi Ferrucci, M.D. · National Institute on Aging (NIA)

Eligibility

Min Age
50 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-02
Completion
2017-10-13

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01517113 on ClinicalTrials.gov