GIP Receptor Antagonist Studies in Humans
NCT02747472 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2017-04-27
Summary
Antagonizing GIP effects during hyperglycaemia in healthy subjects and measurements of insulin secretion.
Conditions
- Glucose Metabolism
Interventions
- DRUG
-
GIP-A
GIP receptor antagonist
- DRUG
-
GIP(1-42)
GIP receptor agonist
- OTHER
-
Saline
Placebo
Sponsors & Collaborators
-
University of Copenhagen
collaborator OTHER -
University Hospital, Gentofte, Copenhagen
lead OTHER
Principal Investigators
-
Filip K Knop, MD, PhD · UHGentofte, Center for Diabetes Research
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- TRIPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 20 Years
- Max Age
- 30 Years
- Sex
- MALE
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2016-04-30
- Primary Completion
- 2016-07-31
- Completion
- 2016-07-31
Countries
- Denmark
Study Locations
More Related Trials
-
GIP Effects at Insulin Induced Hypoglycemia in Patients With Type 2 Diabetes
NCT01414556 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
The Role of Glucose-Dependent Insulinotropic Polypeptide in the Pathological Glucose Homeostasis Of Type 1 Diabetes
NCT03734718 ·Status: COMPLETED ·Phase: NA
-
The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects With and Without Type 1 Diabetes
NCT06881472 ·Status: COMPLETED ·Phase: NA
-
Glucose-dependent Insulinotropic Polypeptide as a Safeguard Against Hypoglycemia in Patients With Type 1 Diabetes
NCT03556098 ·Status: COMPLETED ·Phase: NA
-
The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes
NCT06426823 ·Status: COMPLETED ·Phase: NA
-
GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide
NCT03845179 ·Status: COMPLETED ·Phase: NA
-
The Role of GIP and GLP-2 in Postprandial Splanchnic Blood Flow Distribution and Metabolism
NCT05391581 ·Status: COMPLETED ·Phase: NA
-
Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism
NCT00999271 ·Status: COMPLETED
-
Hyperglycemia and the Extra-pancreatic Effect of Incretins
NCT01749163 ·Status: COMPLETED ·Phase: NA
-
GIP, GLP-1 and GLP-2 in Type 2 Diabetic Hyperglucagonemia
NCT00716170 ·Status: COMPLETED
-
Effect of GLP-1 and GIP on Insulin Secretion in Type-1 Diabetes Mellitus
NCT00603031 ·Status: COMPLETED ·Phase: NA
-
The Effect of GLP-1 on the Inhibition of Glucagon Secretion
NCT01507597 ·Status: COMPLETED ·Phase: NA
-
Glucose-dependent Insulinotropic Polypeptide - New Role as Blood Glucose Stabilizer?
NCT01048268 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance
NCT01173978 ·Status: COMPLETED ·Phase: NA
-
Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals
NCT06934473 ·Status: RECRUITING ·Phase: NA
-
The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function
NCT06194955 ·Status: COMPLETED ·Phase: NA
-
GIP/GLP-1 Co-Activity in Subjects With Overweight and Type 2 Diabetes: Lowering of Food Intake
NCT03526289 ·Status: COMPLETED ·Phase: NA
-
The Insulin Response to the Gut Hormone GIP After Near-normalisation of Plasma Glucose in Patients With Type 2 Diabetes
NCT04228484 ·Status: COMPLETED ·Phase: NA
-
Study of Postprandial Incretin Response in Women With Gestational Diabetes
NCT01274052 ·Status: COMPLETED
-
Glucagon-like Peptide 2 - a Glucose Dependent Glucagonotropic Hormone?
NCT03954873 ·Status: COMPLETED ·Phase: NA
-
Blocking of the Gut Hormone Receptor for Glucagon-like Peptide 2 (GLP-2) by the GLP-2 Receptor Antagonist GLP-2(3-33)
NCT06774807 ·Status: COMPLETED ·Phase: NA
-
Separate and Combined Extrapancreatic Effects of GIP and GLP-1
NCT06895408 ·Status: COMPLETED ·Phase: NA
-
Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus
NCT00655603 ·Status: UNKNOWN ·Phase: NA
-
The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea
NCT03081676 ·Status: COMPLETED ·Phase: NA
-
The Beta Cell Responsiveness to Glucose-dependent Insulinotropic Polypeptide (GIP) With and Without Sulfonylurea in Patients With Type 2 Diabetes
NCT00321321 ·Status: COMPLETED ·Phase: PHASE2