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Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance

NCT01173978 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2011-06-21

No results posted yet for this study

Summary

The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The purpose of this study is to evaluate the insulinotropic affect of the incretin hormones in healthy individuals before and after a deterioration of the glucose homeostasis.

Conditions

Interventions

BEHAVIORAL

Steroid hormone

Steroid hormone: 37,5 mg of prednisolone; High energy diet: 130 % of recommended daily energy intake; Relative physical inactivity: no exercise and at least 8 hours of rest/day

OTHER

No intervention

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • European Foundation for the Study of Diabetes

    collaborator OTHER

  • Glostrup University Hospital, Copenhagen

    lead OTHER

Principal Investigators

  • Katrine B Hansen, MD · Glostrup University Hospital

  • Filip K Knop, MD,PhD · Gentofte University Hospital

  • Tina Vilsbøll, MD,DmSc · Gentofte University Hospital

  • Jens J Holst, MD, DmSc · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-04-30
Primary Completion
2010-07-31
Completion
2010-07-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01173978 on ClinicalTrials.gov