Online Program to Reduce Depression in MS

Summary

This is an international, multicenter, randomized controlled trial of an internet-based CBT intervention for depression (Deprexis) conducted in five MS centers in the US and Germany. The trial consists of a three-arm primary trial phase and an extension phase targeted at maintenance.

Conditions

• Multiple Sclerosis

Interventions

BEHAVIORAL

Deprexis, DeprexisPlus

Online program Deprexis, either as a stand-alone internet-based intervention (Deprexis) or with added standardized email support by a clinical psychologist (DeprexisPlus). In this trial, we will use a Version of Deprexis that has been adapted to MS-specific needs.

Sponsors & Collaborators

• National Multiple Sclerosis Society

  collaborator OTHER

• Universitätsklinikum Hamburg-Eppendorf

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• University of Missouri, Kansas City

  collaborator OTHER

• Penn State University

  collaborator OTHER

• King's College London

  collaborator OTHER

• University Medical Center Goettingen

  collaborator OTHER

• NeuroCure Clinical Research Center, Charite, Berlin

  collaborator OTHER

• Charite University, Berlin, Germany

  lead OTHER

Principal Investigators

• Stefan M Gold, PhD · Charité University, Berlin

• Friedemann Paul, MD · Charité University, Berlin

• Christoph Heesen, MD · Universitätsklinikum Hamburg-Eppendorf

• Nancy Sicotte, MD · Cedars-Sinai Medical Center

• Jared Bruce, PhD · University of Missouri, Kansas City

• Sharon Lynch, MD · University of Missouri, Kansas City

• Peter Arnett, PhD · Penn State University

• Rona Moss-Morris, PhD · King's College London

• Tim Friede, PhD · University Medical Center Goettingen

• Björn Meyer, PhD · GAIA Group

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-02-15

Primary Completion

2021-01-30

Completion

2021-05-01

Countries

• United States
• Germany

Study Locations