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Treating New Learning and Memory Deficits in Progressive Multiple Sclerosis (MS)

NCT02301247 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2017-07-02

No results posted yet for this study

Summary

This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in persons with progressive MS, with outcome measured through three mechanisms: (1) a traditional neuropsychological evaluation (NPE) (2) an assessment of global functioning (AGF) examining the impact of the treatment on daily activities, and (3) an optional functional magnetic resonance imaging (fMRI) scan.

Conditions

  • Multiple Sclerosis, Progressive
  • Cognition - Other
  • Memory Impairment

Interventions

BEHAVIORAL

Memory retraining exercises

Memory retraining exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

BEHAVIORAL

Placebo control memory exercises

Placebo control memory exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).

Sponsors & Collaborators

  • International Progressive MS Alliance

    collaborator UNKNOWN

  • Kessler Foundation

    lead OTHER

Principal Investigators

  • Matthew R Weiner · Kessler Foundation

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
59 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-11-30
Primary Completion
2017-04-02
Completion
2017-04-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02301247 on ClinicalTrials.gov