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Cardiac and Respiratory Function With Non-invasive Ventilation

NCT02699112 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2018-04-11

No results posted yet for this study

Summary

To assess patients with hypercapnic respiratory failure using echocardiography,cardiac output measurements and markers of neural respiratory drive (EMGpara) prior to, during and after non-invasive ventilation (NIV) initiation, and to follow the patients for 3 months. The investigators hypothesize that the improvement in cardiac function and/or respiratory mechanics over time are associated with ongoing improvements in oxygenation, quality of life and exercise capacity.

Conditions

  • OHS
  • Hypercapnic Respiratory Failure

Interventions

OTHER

Parasternal EMG (EMGpara) and Transthoracic Echocardiography

OHS patients recruited will have EMGpara and Transthoracic Echocardiography at admission and when established on NIV at 3 months.

Sponsors & Collaborators

  • University of Padova

    collaborator OTHER

  • King's College London

    collaborator OTHER

  • Lane Fox Respiratory

    collaborator OTHER

  • Guy's and St Thomas' NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Joerg Dr Steier · Guy's and St Thomas' NHS Foundation Trust

  • Marino Dr Phil · Guy's and St Thomas' NHS Foundation Trust

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2018-03-31
Completion
2018-03-31

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02699112 on ClinicalTrials.gov