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Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula

NCT06892912 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-05-18

No results posted yet for this study

Summary

The primary goal of this study is to assess diaphragm function in patients with acute respiratory failure before and during the use of high-flow oxygen and/or non-invasive breathing support. The key question it seeks to answer is:

1\. How do ultrasound measurements of diaphragmatic function vary with different levels of breathing support in patients with acute respiratory failure? Participants with acute respiratory failure will undergo diaphragmatic ultrasound evaluation as part of their standard medical care at various levels of respiratory support.

Conditions

  • Respiration Disorders

Interventions

OTHER

Diaphragmatic ultrasound

Sample: Given the observational nature of the study, a convenience sample will be obtained from all patients admitted to the emergency services and/or ICU with respiratory failure over the course of 1 year. Inclusion Criteria: * Age ≥ 18 years * Hypoxemic respiratory failure (SpO2 \< 88% - PaO2 \< 60 mmHg) or hypercapnic (PaCO2 \> 40) * Need for NIMV and/or HFNC. Exclusion Criteria: * Neuromuscular disease * Pregnancy * Tracheostomy * Rib fractures * Cervical injuries * Diaphragmatic paralysis * Diaphragmatic malformations * Hemodynamic instability * Morbid obesity (BMI \> 35) * Use of sedation and neuromuscular relaxants * Pneumothorax or pneumomediastinum * Poor acoustic window * Critically ill patients with a prognosis of less than 24 hours of life * Patients receiving palliative interventions.

Sponsors & Collaborators

  • Foro Internacional en Cuidado Crítico

    lead OTHER

Principal Investigators

  • Carlos A Santacruz H, MD, PhD · Foro Internacional en Cuidado Crítico

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-02
Primary Completion
2026-10-01
Completion
2026-10-01

Countries

  • Colombia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06892912 on ClinicalTrials.gov