Uterine Transplantation and Pregnancy Induction in Women Affected by Absolute Uterine Infertility
NCT02656550 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38
Last updated 2026-03-23
Summary
This study aims to investigate the treatment of absolute uterine infertility (AUI) due to congenital or surgical absence of a uterus or presence of a nonfunctioning uterus. The investigators will follow a model based on a Swedish study to enroll 20 women with functioning ovaries and successfully transplant the uterus from either a living or cadaveric donor, with the goal of live birth after transplantation.
Conditions
- Absolute Uterine Infertility
Interventions
- PROCEDURE
-
Uterine Transplant
Transplant of a uterus from either a living donor or a deceased donor.,
Sponsors & Collaborators
-
Baylor Research Institute
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 20 Years
- Max Age
- 35 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-11-11
- Primary Completion
- 2026-11-30
- Completion
- 2026-11-30
Countries
- United States
Study Locations
More Related Trials
-
Uterine Transplantation for the Treatment of Uterine Factor Infertility
NCT02573415 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning
NCT01468935 ·Status: COMPLETED
-
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells
NCT02204358 ·Status: UNKNOWN ·Phase: PHASE4
-
AD-SVF Therapy for Refractory Endometrial Infertility
NCT07230600 ·Status: RECRUITING ·Phase: PHASE1
-
Endometrial Biopsy in Infertile Patients
NCT00064935 ·Status: COMPLETED ·Phase: PHASE3
-
Endometrial Injury in Women With Unexplained Infertility
NCT02628756 ·Status: COMPLETED ·Phase: NA
-
Uterus Transplantation From a Multi-organ Donor
NCT03252795 ·Status: RECRUITING ·Phase: NA
-
Efficacy of Uterine Artery Embolization (UAE) in Management of Symptomatic Uterine Adenomyosis
NCT06652945 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Predicting Endometrial Receptivity for Optimal Reproductive Management
NCT04107129 ·Status: COMPLETED
-
Adenomyosis and Pregnancy Outcomes in Women Undergoing Assisted Reproductive Technology Treatment
NCT05418140 ·Status: ACTIVE_NOT_RECRUITING
-
Human Clinical Trial of Uterine Transplantation in the United Kingdom
NCT02388802 ·Status: UNKNOWN ·Phase: NA
-
Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma
NCT06261658 ·Status: RECRUITING ·Phase: NA
-
The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy
NCT02335203 ·Status: UNKNOWN ·Phase: PHASE2
-
Endometriosis and Obstetric Outcomes
NCT04664660 ·Status: UNKNOWN
-
Didroxyprogesterone Promotes Natural Pregnancy in Infertile Patients With Endometriosis
NCT05467852 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Endometrial Injury for Assisted Reproduction
NCT01132144 ·Status: TERMINATED ·Phase: PHASE3
-
Autologous Ovarian Tissue Transplantation
NCT03496636 ·Status: RECRUITING ·Phase: NA
-
The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF
NCT04597463 ·Status: COMPLETED ·Phase: NA
-
Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchyma Stem Cells
NCT02313415 ·Status: COMPLETED ·Phase: NA
-
Endometrial Biopsy Prior to IVF in Those Patients With Prior Implantation Failure
NCT01800513 ·Status: UNKNOWN ·Phase: NA
-
Amnion Bilayer and Stem Cell Combination Therapy on Thin Endometrium Infertile Patients
NCT04676269 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial
NCT02180256 ·Status: TERMINATED ·Phase: NA
-
Feasibility Study of the AblaCare System in Transvaginal Ablation of Ovarian Tissue Under ULTRAsound Visualization in Women With Infertility Due to Polycystic Ovary Syndrome
NCT05320289 ·Status: COMPLETED ·Phase: NA
-
Uterine Artery Embolization and Pelvic Floor Symptoms
NCT00827645 ·Status: WITHDRAWN
-
Endometrial Local Injury and Implantation Failure
NCT00837733 ·Status: COMPLETED ·Phase: NA